Should clofibrate still be prescribed?
نویسنده
چکیده
منابع مشابه
Comparing the effect of clofibrate and phenobarbital on the newborns with hyperbilirubinemia
The aim of treating hyperbilirubinemia is preventing the serum bilirubin to reach neurotoxic levels, which is done by phototherapy or blood transfusion. However, pharmacological treatments still remain vague. Therefore the effects of adding either clofibrate or phenobarbital on treatment outcomes was evaluated in icteric non-hemolitic newborns. Ninety neonates were divided in three groups. Two ...
متن کاملEffect of clofibrate on serum triglyceride and cholesterol after intravenous lipid in very low birth weight neonates
Background Lipoprotein lipase activity can be increased by clofibrate. Clofibrate is used to reduce serum triglyceride level in adults. The aim of this study was to determine the effect of clofibrate on serum triglyceride and cholesterol level after administration of intravenous lipid in very low birth weight neonates. Method In a randomized double blind placebo – controlled study, 60 very lo...
متن کاملClofibrate-induced myopathy in patients with diabetes insipidus.
Clofibrate has been considered to be a relatively safe antidiuretic in the treatment of diabetes insipidus. However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions. Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus...
متن کاملSuppression of tumor-associated hyperfibrinogenemia and free fatty acidemia with p-phenoxybenzalbutyrate (clofibrate).
Previous work in our laboratory has indicated that free fatty acids stimulate synthesis of fibrinogen by the liver. The effect of the hypolipidemic agent clofibrate on hyperfibrinogenemia associated with tumors was evaluated by monitoring clofibrate-induced changes in plasma fibrinogen concentration and biosynthesis of the protein in Buffalo rats implanted with a localized, nonmetastasizing neo...
متن کاملEvaluation of the Effect of Oral Clofibrate Intake on Neonatal Total Serum Bilirubin: a Randomized Clinical Trial
Background: Clofibrate is a pharmacological agent, which affects the lipid metabolism. This compound could be involved in bilirubin accumulation and excretion process. Therefore, this study aimed to evaluate the effect of oral clofibrate intake on total serum bilirubin (TSB) of neonates hospitalized at Khatam Hospital. Methods: This clinical trial was conducted on 73 neonates with hyperbilirub...
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ورودعنوان ژورنال:
- BMJ
دوره 305 6850 شماره
صفحات -
تاریخ انتشار 1992